[Effect of enterosorption on immunologic parameters of patients with colorectal cancer in the postoperative period].

Our investigation was carried out on an assumption that end results among patients radically-treated for colorectal cancer might be improved by use of enteroabsorption. The study group included 17, controls--13 patients with diagnostically verified stage I-III tumors. Mixed sorbent (microcellulose + polysorb) (6g) was administered, once a week, on the average of 20 days after operation. Immunological vigor was assayed 3 weeks after surgery: immunoglobulin levels--by turbodimetric method, cellular profile of lymphocytes--monoclonal antibodies to cell markers CD3, CD4, CD8, CD16 and CD22. As a result of adjuvant treatment CD22 (B-lymphocytes) concentration increased significantly--from 17.70 to 21.66 (22%), while CD16 (innate killers) both in absolute numbers (19%) and by percentage points (9%). Circulating immunocomplex levels in the sorbent-treatment group were significantly lower (37.44 ths units) than in control (48 ths units) (average 28%). No relapse or metastases were reported in either group.

[Action of chlorophos on the liver mitochondrial membranes in the white rat]. / Deistvie khlorofosa na mitokhondrial'nye membrany pecheni belykh krys.

Injection of chlorophos (300 mg/kg, i. m.) to rats produced after 4 hours an elevation of phospholipid level in liver mitochondria by 35.8% on an average. The central cholinolytic cyclosil did not prevent the effect from being realized. Chlorophos (10(-7)-10(-5)M) in vitro failed to influence the phospholipid level in isolated mitochondria but their content in intact mitochondria was appreciably diminished after incubation. The rate of phospholipid biosynthesis in the mitochondrial membranes was not affected by chlorophos poisoning. It is suggested that the effect of chlorophos is mediated by its interaction with mitochondrial phospholipases.